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For any copyright, please send me a message. A powerful cholesterol jab given twice a year could become an alternative to statins for millions, a major trial suggests.Doctors say inclisiran – a revolutionary ‘gene-silencing’ drug – has phenomenal potential to transform patients’ lives.A global trial, led by Imperial College London, has shown the injection safely reduces ‘bad’ LDL cholesterol by 50 per cent – a similar impact to high-dose statins.But instead of having to take a pill every day – which puts many off statins – patients just have to visit a nurse for a jab once every six months. Study leader Professor Kausik Ray, presenting his results yesterday at the European Society of Cardiology congress in Paris, said: ‘For people faced with the concept of taking 365 pills a year for the next few decades, this in comparison is much more tolerable.’.The small company which makes it said it is planning to apply for a medicine licence in the US next year and the UK the year after. Initially most patients will have the jab alongside their statins, which Professor Ray believes could benefit up to 700,000 in the UK.But he believes the jab could eventually be used as an alternative for those who cannot tolerate the side effects of statins, or as a convenient alternative for those who simply do not like taking pills. In time, Professor Ray believes, the jab could even be offered just once a year, and could be given to millions at low risk.‘It is a game-changer for people to manage their cholesterol,’ he said. ‘The convenience is key. People have lives, they have jobs. We have to move ourselves to the patient, to make that difference.’ He added: ‘I think statins will always be the first-line treatment because they are so cheap. But in the future, could it replace statins for some patients? That could be the case.’ Roughly six million people in Britain are prescribed statins at a cost of about £20 a year. They are thought to prevent about 80,000 heart attacks and strokes a year. Share this article Share But research published by Nottingham University suggested 49 per cent of those prescribed the pills do not see their cholesterol drop to a healthy level – either because they are on the wrong dose or because they simply stop taking them.Professor Naveed Sattar, consultant in metabolic medicine at Glasgow University, said that the ‘fire and forget’ approach of a six-monthly jab would be hugely popular.‘Taking a daily tablet, for many people, is a pain,’ he said. ‘Anything we can do to reduce this burden is positive. We need to learn more about long-term safety – but otherwise this is very positive.’Inclisiran is among the first in a wave of new ‘gene silencing’ drugs which block RNA – the ‘messenger’ of the geneti
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